Endocrine Abstracts

Introduction: Dermatomyositis is an inflammatory connective-tissue disease, characterized by inflammation of the muscles and the skin. It is more frequent among women and in 25% of cases it is related to malignancy, such as ovarian, breast, colon cancer, melanoma, non-Hodgkin’s lymphomas, lung cancer, myelo-hyperplastic syndromes, and nasopharyngeal cancer. In 1/3 of cases dermatomyositis precedes malignancy, in 1/3 they present simultaneously, and in the remaining 1/3 o...

Objective: To evaluate and compare the effects of metformin used as a single-agent therapy and in combination with gliclazide modified release (MR) on glycoregulation and lipid profile in patients with type 2 diabetes mellitus (T2DM).Methodology: A multi-center observational epidemiological study was carried out in patients with T2DM, divided in two groups according to the current type of treatment: first group was on monotherapy with metformin in daily ...

Background: Due to its efficacy and safety, metformin is the most commonly used drug in a single-agent therapy of type 2 diabetes mellitus (T2DM), after lifestyle modifications failed to obtain a desirable effects. Despite his main effects in improving glycemic control, it is also stated that it has a beneficial effects on lipid profile, which may be attributable to improved insulin sensitivity, weight loss and reduction of irreversibly glycated low density lipoprotein cholest...

Introduction: Adrenocortical carcinoma is a rare tumor with an incidence of 1 per million per year. It occurs in two age groups: in children under 5 years old and in adults from 4th to 6th decade of life. It is potentially curable at an early stage, unfortunatelly, about 70% of these tumors are detected late. Functional carcinomas are present with about 60% with endocrine syndrom: Cushing syndrome (30%); Virilization and premature puberty (22%); Feminization (10%); Primary hyp...